A simple, accurate, and precise Simultaneous Equation spectrophotometric method was developed for simultaneous determination of Ketorolac Tromethamine and Olopatadine Hydrochloride. The method involves determination of Ketorolac Tromethamine at 320.0 nm and Olopatadine Hydrochloride at 206.0 nm. Both drugs follow Beer-Lambert’s law over the concentration range of 4-20 μg/ml and 2-10 μg/ml for Ketorolac Tromethamine and Olopatadine Hydrochloride respectively. The % assay of the drugs was found to 98.99±0.7619 and %99±1.3228 for Ketorolac Tromethamine and Olopatadine Hydrochloride respectively. Validation of the proposed method was carried out for its linearity, accuracy, precision, LOD, and LOQ, according to ICH guidelines. The recovery of the Ketorolac Tromethamine and Olopatadine Hydrochloride were found to 100.18±0.072167% and 99.55±0.010516% for Ketorolac Tromethamine and Olopatadine Hydrochloride respectively. The proposed methods can be successfully applied in routine work for determination of Ketorolac Tromethamine and Olopatadine Hydrochloride in pharmaceutical dosage form.
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